Coordination: Elbio Leiguez Junior, Morena Brazil Martins Sant'Anna,

Workload:30

Credit: 0

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The aim of the course is to provide students with knowledge in basic sciences such as: cell biology, biochemistry, pharmacology, immunology and pathology, since they are essential for the development of projects in Toxinology. Toxinology has an interdisciplinary character combining sciences such as cell biology, biochemistry, pharmacology, immunology and pathology. In this sense, the Graduate Program in Toxinology attracts students from different undergraduate courses, with a wide range of disciplines, sometimes with little foundation in basic areas. For a better follow-up of projects in Toxinology, it is important to provide a discipline that covers these areas. This discipline will contribute to the training of qualified human resources and will be a tool to stimulate the entry of new students into the Graduate Program in Toxinology. This course will target PPGTox Master's students, students of the Professional Improvement Program of the Butantan Institute, and other newly graduated students. Program content: 1) Notions of Cell Biology: Animal cell structural and functional biology and main classes of receptors involved in cell signaling; 2) Notions of biochemistry: structure and function, nucleic acids, gene duplication, transcription and translation, main techniques used in molecular biology; 3) Notions of Pharmacology: pharmacokinetics: absorption, distribution, metabolization and elimination of drugs and pharmacodynamics; 4) Notions of immunology: introduction to the immune system, definition of antigens and antibodies, innate and acquired immune response, immunodiagnostic; 5) Pathology: hemostasis and inflammation

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Coordination: Joanita Lopes Fernandes da Costa,

Workload:6

Credit: 0

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Coordination: Joanita Lopes Fernandes da Costa,

Workload:6

Credit: 0

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Coordination: Patrícia Emília Braga,

Workload:48

Credit: 3

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Objectives: To introduce basic concepts related to descriptive analysis and data statistical inference and the elaboration and interpretation of a hypothesis test. Rationale: Intended to offer to graduate students the subsidies for explanatory analysis and for statistical inference of research data using statistical tools of Excel. Program content: 1- Biostatistics: definition and relevance. 2- Types of variables. 3- Tabular and graphical presentation. 4- Measures of central tendency, measures of dispersion or variability, Pearson’s coefficient of variation. 5- Percentiles and boxplot graph. 6- Normal Distribution. 7- Estimation of population parameters by interval. 8- Hypothesis Testing. Value of p. 9- Chi-square test and Fisher's test. 10- Student t test (paired and unpaired). ANOVA (Bonferroni). 11- Correlation and notions of linear regression. 12- Some non-parametric tests (Mann-Whitney, Wilcoxon, Kruskal-Wallis, Spearman's correlation).

Bibliography:
1- Introdução à Estatística Médica. Soares JF, Siqueira AL. 2a ed. Belo Horizonte: COOPMED, 2002. 2- Estatística Básica. Bussab WO, Morettin PA. 5a ed. São Paulo: Editora Saraiva, 2006. 3 - Introdução à Estatística. Triola MF. 9a ed. Rio de Janeiro: LTC – Livros Técnicos e Científicos Editora S.A., 2005. 4 - Essential Medical Statistics. Kirkwood BR, Sterne JAC. 2nd Ed. Malden, MA: Blackwell Publishing, 2006. 5 - Estatística para ciências humanas. Levin J, Fox JA. 9ª ed. São Paulo: Pearson, 2004. 6 - Delineando a pesquisa clínica. Hulley SB et al 2ª ed. Porto Alegre: ARTMED, 2003. 7 - Estatística não-paramétrica para ciências do comportamento. Siegel S, Castellan Jr NJ. 2ª ed. Porto Alegre: ARTMED, 2006.